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Article

Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Apr 2013

Lane Rachel F, Steele John W, Cai Dongming, Ehrlich Michelle E, Attie Alan D, Gandy Sam

Abstract excerpt

Endosomal sorting of the Alzheimer amyloid precursor protein (APP) plays a key role in the biogenesis of the amyloid-β (Aβ) peptide. Genetic lesions underlying Alzheimer's disease (AD) can act by interfering with this physiological process. Specifically, proteins involved in trafficking between endosomal compartments and the trans-Golgi network (TGN) [including the retromer complex (Vps35, Vps26) and its putative...

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Identifiers

PMID: 23595767
DOI: 10.1523/JNEUROSCI.5270-12.2013
PMCID: PMC3696125

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide.PMID 23595767Read ↗

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