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Trans-(±)-kusunokinin alters EMT markers and inhibits lung cancer cells by hindering polyol pathway

2024-10-25

Abstract excerpt

Trans-(±)-kusunokinin (KU), a potential anticancer agent, has been reported as an AKR1B1 inhibitor, leading to the inhibition of oxidative stress and alteration of EMT-related proteins in aggressive breast cancer. Overexpression of AKR1B1 is associated with a poor prognosis in non-small cell lung cancer (NSCLC). Therefore, we aimed to elucidate the mechanism of action by which KU mediates its effects through AKR1B...

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Literature Corpus work
c06cb742-4e2a-5861-9ea6-08b8b227ec78
DOI
10.22541/au.172988491.12673017/v1
Open publication

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Trans-(±)-kusunokinin alters EMT markers and inhibits lung cancer cells by hindering polyol pathwayDOI 10.22541/au.172988491.12673017/v1
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