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Article

Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells

17 Jan 2018

Abstract excerpt

Abstract Cancer cells alter their metabolism to support their malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-B1 (AKR1B1) strongly correlates with epithelial-to-mesenchymal transition (EMT). This association was confirmed in samples from lung cancer patients and from an EMT-driven colon cancer mouse model with p53 deletion. In...

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PMID: 29343522
DOI: 10.1158/0008-5472.can-17-2834

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