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Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

17 Mar 2023

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a complex process with a primordial role in cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal phenotype. This transformation plays a pivotal role in tumor progression and self-renewal, and exacerbates resistance to apoptosis and chemotherapy. EMT can be initiated and promoted by deregulated oncogenic signaling pathways, hypoxia, and...

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PMID: 36929669
DOI: 10.1002/med.21948

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