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Identification of Determinants that Allow Maintenance of High-Level Fluoroquinolone Resistance in <i>Acinetobacter baumannii</i>

2023-10-03

Abstract excerpt

Acinetobacter baumannii is associated with multidrug resistant (MDR) infections in healthcare settings, with fluoroquinolones such as ciprofloxacin being currently ineffective. Clinical isolates largely harbor mutations in the GyrA and TopoIV fluoroquinolone targets, as well as mutations that increase expression of drug resistance-nodulation-division (RND) efflux pumps. Factors critical for maintaining fitness lev...

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Literature Corpus work
222f6ccb-bcc7-55aa-8e33-3949e533d3b3
DOI
10.1101/2023.10.03.560562
Open publication

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