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Article

Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii.

Molecular microbiology - 1 Dec 2020

Leus Inga V, Adamiak Justyna, Trinh Anhthu N, Smith Richard D, Smith Lauren, Richardson Sophie, Ernst Robert K, Zgurskaya Helen I

Abstract excerpt

Multidrug resistant (MDR) strains of Acinetobacter baumannii present a serious clinical challenge. The development of antibiotic resistance in this species is enabled by efflux pumps of the Resistance-Nodulation-Division (RND) superfamily of proteins creating an efficient permeability barrier for antibiotics. At least three RND pumps, AdeABC, AdeIJK, and AdeFGH are encoded in the A. baumannii genome and are...

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PMID: 32858760
DOI: 10.1111/mmi.14594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii.PMID 32858760Read ↗

Contribution of RND superfamily multidrug efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence factors in multidrug-resistant Acinetobacter baumannii AYESemantic proximity Read ↗

RND pumps across the genus Acinetobacter: AdeIJK is the universal efflux pumpSemantic proximity Read ↗

RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations.Semantic proximity Read ↗

Overexpression of Resistance-Nodulation-Cell Division Pump AdeFGH Confers Multidrug Resistance in <i>Acinetobacter baumannii</i>Semantic proximity Read ↗

Characteristics and Diversity of Mutations in Regulatory Genes of Resistance-nodulation-cell Division Efflux Pumps in Association With Drug-resistant Clinical Isolates of Acinetobacter BaumanniiSemantic proximity Read ↗

Characteristics and diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with drug-resistant clinical isolates of Acinetobacter baumannii.Semantic proximity Read ↗

Acinetobacter baumannii Survival under Infection-Associated Stresses Depends on the Expression of Resistance–Nodulation–Division and Major Facilitator Superfamily Efflux PumpsSemantic proximity Read ↗

Distribution and expression of the Ade multidrug efflux systems in Acinetobacter baumannii clinical isolatesSemantic proximity Read ↗

AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in <i>Acinetobacter baumannii</i>Semantic proximity Read ↗

Resistance to pentamidine is mediated by AdeAB, regulated by AdeRS, and influenced by growth conditions in Acinetobacter baumannii ATCC 17978.Semantic proximity Read ↗

RND pumps across the <i>Acinetobacter</i> genus; AdeIJK is the ancestral efflux systemSemantic proximity Read ↗

Role of efflux pumps in reduced susceptibility to tigecycline in Acinetobacter baumanniiSemantic proximity Read ↗

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