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Overexpression of Resistance-Nodulation-Cell Division Pump AdeFGH Confers Multidrug Resistance in <i>Acinetobacter baumannii</i>

10 Aug 2010

Abstract excerpt

Acinetobacter baumannii is a major nosocomial pathogen which frequently develops multidrug resistance by acquisition of antibiotic resistance genes and overexpression of intrinsic efflux systems, such as the RND efflux pumps AdeABC and AdeIJK. A third RND system was characterized by studying spontaneous mutants BM4663 and BM4664, which were selected in the presence of chloramphenicol and norfloxacin,...

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PMID: 20696879
DOI: 10.1128/aac.00155-10

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Overexpression of Resistance-Nodulation-Cell Division Pump AdeFGH Confers Multidrug Resistance in <i>Acinetobacter baumannii</i>PMID 20696879Read ↗

AdeIJK, a Resistance-Nodulation-Cell Division Pump Effluxing Multiple Antibiotics in <i>Acinetobacter baumannii</i>Semantic proximity Read ↗

Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii.Semantic proximity Read ↗

RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations.Semantic proximity Read ↗

RND pumps across the genus Acinetobacter: AdeIJK is the universal efflux pumpSemantic proximity Read ↗

Contribution of RND superfamily multidrug efflux pumps AdeABC, AdeFGH, and AdeIJK to antimicrobial resistance and virulence factors in multidrug-resistant Acinetobacter baumannii AYESemantic proximity Read ↗

Characteristics and Diversity of Mutations in Regulatory Genes of Resistance-nodulation-cell Division Efflux Pumps in Association With Drug-resistant Clinical Isolates of Acinetobacter BaumanniiSemantic proximity Read ↗

RND pumps across the <i>Acinetobacter</i> genus; AdeIJK is the ancestral efflux systemSemantic proximity Read ↗

Characteristics and diversity of mutations in regulatory genes of resistance-nodulation-cell division efflux pumps in association with drug-resistant clinical isolates of Acinetobacter baumannii.Semantic proximity Read ↗

Antibiotic Resistance and Expression Of Resistance‐Nodulation‐Division Pump‐ and Outer Membrane Porin‐Encoding Genes in <i>Acinetobacter</i> Species Isolated from Canadian HospitalsSemantic proximity Read ↗

Phylogenomic and phenotypic analyses highlight the diversity of antibiotic resistance and virulence in both human and non-human <i>Acinetobacter baumannii</i>Semantic proximity Read ↗

Screening and quantification of the expression of antibiotic resistance genes in Acinetobacter baumannii with a microarray.Semantic proximity Read ↗

Expression of the resistance-nodulation-cell division pump AdeIJK in Acinetobacter baumannii is regulated by AdeN, a TetR-type regulator.Semantic proximity Read ↗

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