Article
In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa.
Proceedings of the National Academy of Sciences of the United States of America - 5 Apr 2005
Cideciyan Artur V, Jacobson Samuel G, Aleman Tomas S, Gu Danian, Pearce-Kelling Susan E, Sumaroka Alexander, Acland Gregory M, Aguirre Gustavo D
Abstract excerpt
Genetic and environmental factors modify the severity of human neurodegenerations. Retinal degenerations caused by rhodopsin gene mutations show severity differences within and between families and even within regions of the same eye. Environmental light is thought to contribute to this variation. In the naturally occurring dog model of the human disorder, we found that modest light levels, as used in routine...
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