Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysmorphic photoreceptors in a P23H mutant rhodopsin model of retinitis pigmentosa are metabolically active and capable of regenerating to reverse retinal degeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Feb 2012

Lee Damian C, Vazquez-Chona Felix R, Ferrell W Drew, Tam Beatrice M, Jones Bryan W, Marc Robert E, Moritz Orson L

Abstract excerpt

This study evaluated the capacity of Xenopus laevis retina to regenerate photoreceptor cells after cyclic light-mediated acute rod photoreceptor degeneration in a transgenic P23H mutant rhodopsin model of retinits pigmentosa. After discontinuation of cyclic light exposure, we monitored histologic progression of retinal regeneration over a 3 week recovery period. To assess their metabolomic states, contralateral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histidine
Share to Nerve Regeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proline

Share to Retinal Degeneration

Share to Retinal Rod Photoreceptor Cells

Share to Retinitis Pigmentosa

Share to Rhodopsin

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 22323724
DOI: 10.1523/JNEUROSCI.4752-11.2012
PMCID: PMC3710121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysmorphic photoreceptors in a P23H mutant rhodopsin model of retinitis pigmentosa are metabolically active and capable of regenerating to reverse retinal degeneration.PMID 22323724Read ↗

Transcriptomic remodeling of the retina in a Zebrafish model of Retinitis PigmentosaSemantic proximity Read ↗

Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration.Semantic proximity Read ↗

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and RepairSemantic proximity Read ↗

Single Cell RNA Sequencing Analysis of Mouse Retina Identifies a Subpopulation of Muller Glia Involved in Retinal Recovery From Injury in the FCD-LIRD ModelSemantic proximity Read ↗

Photoreceptor metabolic reprogramming: current understanding and therapeutic implicationsSemantic proximity Read ↗

Retinal remodeling triggered by photoreceptor degenerations.Semantic proximity Read ↗

Metabolomics Effects of Folding Correction in Retinitis Pigmentosa Rhodopsin Mutant P23A.Semantic proximity Read ↗

Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease.Semantic proximity Read ↗

Unveiling the Cellular and Molecular Mechanisms of Diabetic Retinopathy with Human Retinal OrganoidsSemantic proximity Read ↗

Homeostatic plasticity triggered by rod photoreceptor degenerative disease is associated with maintenance of sensitive night visionSemantic proximity Read ↗

Synchronized photoactivation of T4K rhodopsin causes a chromophore-dependent retinal degeneration that is moderated by interaction with phototransduction cascade componentsSemantic proximity Read ↗

Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.