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Article

ER stress in retinal degeneration: a target for rational therapy?

Trends in molecular medicine - 1 Aug 2011

Griciuc Ana, Aron Liviu, Ueffing Marius

Abstract excerpt

Mutations that cause rhodopsin misfolding and retention within the endoplasmic reticulum (ER) are a prominent cause of retinitis pigmentosa. Here, we discuss the hypothesis that the failure of photoreceptor neurons to adapt to the stress caused by rhodopsin accumulation in the ER leads to a global collapse of homeostasis and to retinal degeneration. We review the molecular mechanisms underlying the activity of...

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Source

Identifiers

PMID: 21620769
DOI: 10.1016/j.molmed.2011.04.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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