Article

Kindlin-3 Mutation in Mesenchymal Stem Cells Results in Enhanced Chondrogenesis

2019-03-15

Abstract excerpt

<h4>ABSTRACT</h4> Identifying patient mutations driving skeletal development disorders has driven our understanding of bone development. Integrin adhesion deficiency disease is caused by a Kindlin-3 (fermitin family member 3) mutation and its inactivation results in bleeding disorders and osteopenia. In this study, we uncover a role for Kindlin-3 in the differentiation of bone marrow mesenchymal stem cells (BMSCs...

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Literature Corpus work: c04c2221-46be-52c8-abcc-0a599d143eca
DOI: 10.1101/578690

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