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Article

Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis.

Experimental cell research - 15 Feb 2021

Kerr Bethany A, Shi Lihong, Jinnah Alexander H, Harris Koran S, Willey Jeffrey S, Lennon Donald P, Caplan Arnold I, Byzova Tatiana V

Abstract excerpt

Identifying patient mutations driving skeletal development disorders has driven our understanding of bone development. Integrin adhesion deficiency disease is caused by a Kindlin-3 (fermitin family member 3) mutation, and its inactivation results in bleeding disorders and osteopenia. In this study, we uncover a role for Kindlin-3 in the differentiation of bone marrow mesenchymal stem cells (BMSCs) down the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33417921
DOI: 10.1016/j.yexcr.2020.112456
PMCID: PMC7874523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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