Article

AD-HIES Fracture Healing Impaired by STAT3 Dysfunction Affecting Stem Cell Mobilization

2025-04-11

Abstract excerpt

<title>Abstract</title> <p>Recurrent fractures and delayed fracture healing are key clinical manifestations of autosomal dominant hyper-IgE syndrome (AD-HIES), caused by heterozygous mutations and loss-of-function variants in the signal transducer and activator of transcription 3 (STAT3) gene. However, the precise mechanisms underlying these defects remain unclear, and effective therapies are limited. In this stu...

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Literature Corpus work: c5ab4767-ed19-5cc3-99c2-71dbdc7c8d98
DOI: 10.21203/rs.3.rs-6381295/v1

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