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Article

New insight on FGFR3-related chondrodysplasias molecular physiopathology revealed by human chondrocyte gene expression profiling.

PloS one - 29 Oct 2009

Schibler Laurent, Gibbs Linda, Benoist-Lasselin Catherine, Decraene Charles, Martinovic Jelena, Loget Philippe, Delezoide Anne-Lise, Gonzales Marie, Munnich Arnold, Jais Jean-Philippe, Legeai-Mallet Laurence

Abstract excerpt

Endochondral ossification is the process by which the appendicular skeleton, facial bones, vertebrae and medial clavicles are formed and relies on the tight control of chondrocyte maturation. Fibroblast growth factor receptor (FGFR)3 plays a role in bone development and maintenance and belongs to a family of proteins which differ in their ligand affinities and tissue distribution. Activating mutations of the...

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Source

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Identifiers

PMID: 19898608
DOI: 10.1371/journal.pone.0007633
PMCID: PMC2764091

Genes

FGFR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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