Article

Myeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy

2022-12-13

Abstract excerpt

<title>Abstract</title> <p>Cardiotoxicity is a major complication of anthracycline therapy that negatively impacts prognosis. Effective pharmacotherapies for prevention of anthracycline-induced cardiomyopathy (AICM) are currently lacking. Increased plasma levels of the neutrophil-derived enzyme myeloperoxidase (MPO) predict occurrence of AICM in humans. We hypothesized that MPO release causally contributes to AIC...

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Literature Corpus work: d22eae65-09af-5c19-915f-aa15789ef1d2
DOI: 10.21203/rs.3.rs-2219349/v1

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