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Intratumoral delivered novel circular mRNA encoding cytokines for immune modulation and cancer therapy

17 Sept 2022

Abstract excerpt

The success of the two mRNA vaccines developed by Moderna and BioNTech during the COVID-19 pandemic increased research interest into the application of mRNA technologies. Compared with the canonical linear mRNA used in these vaccines, circular mRNA has been found to mediate more potent and durable protein expression and demands a simpler manufacturing procedure. However, the application of circular mRNA is still...

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PMID: 36156907
DOI: 10.1016/j.omtn.2022.09.010

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