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Article

Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate.

Nature communications - 23 Sept 2023

Rüttermann Maximilian, Koci Michelle, Lill Pascal, Geladas Ermis Dionysios, Kaschani Farnusch, Klink Björn Udo, Erdmann Ralf, Gatsogiannis Christos

Abstract excerpt

The double-ring AAA+ ATPase Pex1/Pex6 is required for peroxisomal receptor recycling and is essential for peroxisome formation. Pex1/Pex6 mutations cause severe peroxisome associated developmental disorders. Despite its pathophysiological importance, mechanistic details of the heterohexamer are not yet available. Here, we report cryoEM structures of Pex1/Pex6 from Saccharomyces cerevisiae, with an endogenous...

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Identifiers

PMID: 37741838
DOI: 10.1038/s41467-023-41640-9
PMCID: PMC10518020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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