Article

A machine learning model that identifies neoantigen-reactive CD8+ T cells in human gastrointestinal cancer

2022-10-21

Abstract excerpt

It appears that tumor-infiltrating neoantigen-reactive CD8 + T cells are the primary driver of immune responses to gastrointestinal cancer in patients. By mapping neoantigen-reactive T cells from the single-cell transcriptomes of thousands of tumor-infiltrating lymphocytes, we developed a 26-gene machine learning model for the identification of neoantigen-reactive T cells. In both training and test sets, the model...

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Literature Corpus work: c00ee981-e199-56ff-a9e1-afea8bb3b7d5
DOI: 10.21203/rs.3.rs-2188420/v1

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