Article
Identification and Phenotypic Characterization of Neoantigen-Specific Cytotoxic CD4+ T Cells in Endometrial Cancer.
Cancer immunology research - 3 Feb 2025
Fusagawa Minami, Tokita Serina, Murata Kenji, Mariya Tasuku, Umemoto Mina, Sugita Shintaro, Matsuo Kazuhiko, Hirohashi Yoshihiko, Saito Tsuyoshi, Kanaseki Takayuki, Torigoe Toshihiko
Abstract excerpt
Tumor-reactive CD4+ T cells often accumulate in the tumor microenvironment (TME) in human cancer, but their functions and roles in antitumor responses remain elusive. Here, we investigated the immunopeptidome of HLA class II-positive (HLA-II+) endometrial cancer with an inflamed TME using a proteogenomic approach. We identified HLA-II neoantigens, one of which induced polyclonal CD4+ tumor-infiltrating lymphocyte...
Read the complete abstract on PubMedTopics
- Humans
- Female
- Endometrial Neoplasms
- Tumor Microenvironment
- Antigens, Neoplasm