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Article

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes

13 Oct 2019

Abstract excerpt

Tumor-resident lymphocytes can mount a response against neoantigens expressed in microsatellite-stable gastrointestinal (GI) cancers, and adoptive transfer of neoantigen-specific lymphocytes has demonstrated antitumor activity in selected patients. However, whether peripheral blood could be used as an alternative minimally invasive source to identify lymphocytes targeting neoantigens in patients with GI cancer...

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PMID: 31609250
DOI: 10.1172/jci127967

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