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Opportunities for Synthetic Biology in Antibiotics: Expanding Glycopeptide Chemical Diversity

17 Dec 2012

Abstract excerpt

Synthetic biology offers a new path for the exploitation and improvement of natural products to address the growing crisis in antibiotic resistance. All antibiotics in clinical use are facing eventual obsolesce as a result of the evolution and dissemination of resistance mechanisms, yet there are few new drug leads forthcoming from the pharmaceutical sector. Natural products of microbial origin have proven over...

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PMID: 23654249
DOI: 10.1021/sb300092n

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