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A novel antibiotic class targeting the lipopolysaccharide transporter

3 Jan 2024

Abstract excerpt

Abstract Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options 1 . No new antibiotic chemical class with activity against A. baumannii has reached patients in over 50 years 1 . Here we report the identification and optimization of tethered macrocyclic peptide (MCP) antibiotics with potent antibacterial activity against CRAB. The mechanism of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38172634
DOI: 10.1038/s41586-023-06873-0

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