Article

Tumor-Associated Macrophages Expand Chemoresistant, Ovarian Cancer Stem-Like Cells

2023-07-19

Abstract excerpt

The persistence of ovarian cancer stem-like cells (OvCSCs) after chemotherapy resistance has been implicated in relapse. However, the ability of these relatively quiescent cells to produce the robust tumor regrowth necessary for relapse remains an enigma. Since normal stem cells exist in a niche, and tumor-associated macrophages (TAMs) are the highest abundance immune cell within ovarian tumors, we hypothesized th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bfd752b7-2603-537d-8310-29fefa20f0dd
DOI: 10.1101/2023.07.17.549067

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumor-Associated Macrophages Expand Chemoresistant, Ovarian Cancer Stem-Like CellsDOI 10.1101/2023.07.17.549067Read

Chemotherapy Enriches for Proinflammatory Macrophage Phenotypes that Support Cancer Stem-Like Cells and Disease Progression in Ovarian Cancer.Semantic proximity Read

Co-culture of ovarian cancer stem-like cells with macrophages induced SKOV3 cells stemness via IL-8/STAT3 signaling.Semantic proximity Read

Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance.Semantic proximity Read

A comprehensive overview of ovarian cancer stem cells: correlation with high recurrence rate, underlying mechanisms, and therapeutic opportunitiesSemantic proximity Read

Mesenchymal stromal cells release CXCL1/2/8 and induce chemoresistance and macrophage polarizationSemantic proximity Read

Ovarian cancer stem-like cells elicit the polarization of M2 macrophages.Semantic proximity Read

Isolation and characterization of stem-like cells from a human ovarian cancer cell line.Semantic proximity Read

Fallopian tube single cell analysis reveals myeloid cell alterations in high-grade serous ovarian cancerSemantic proximity Read

Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic StrategiesSemantic proximity Read

Ovarian Cancer Cells Direct Monocyte Differentiation Through A Non-Canonical PathwaySemantic proximity Read

Cancer Stem Cells in Ovarian Cancer—A Source of Tumor Success and a Challenging Target for Novel TherapiesSemantic proximity Read

TLR2 enhances ovarian cancer stem cell self-renewal and promotes tumor repair and recurrenceSemantic proximity Read