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Article

Co-culture of ovarian cancer stem-like cells with macrophages induced SKOV3 cells stemness via IL-8/STAT3 signaling.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jul 2018

Ning Yingxia, Cui Yinghong, Li Xiang, Cao Xiaocheng, Chen A, Xu Chang, Cao Jianguo, Luo Xin

Abstract excerpt

Among recent concepts in the cancer biology field, the tumor microenvironment is highly associated with cancer stem cells, and plays a key role in tumor progression. This study aimed to explore the mechanism that the stemness induction of SKOV3 cell line by macrophages derived from THP-1 cells, which was co-cultured with SKOV3-derived ovarian cancer stem-like cells (OCSLCs). Sphere formation, soft agar colony...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29656182
DOI: 10.1016/j.biopha.2018.04.022

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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