Article

Cooperativity and induced oligomerisation control the interaction of SARS-CoV-2 with its cellular receptor and patient-derived antibodies

2023-09-15

Abstract excerpt

Viral entry is mediated by oligomeric proteins on the virus and cell surfaces. The association is therefore open to multivalent interactions between these proteins, yet such recognition is typically rationalised as affinity between monomeric equivalents. As a result, assessment of the thermodynamic mechanisms that control viral entry has been limited. Here, we use mass photometry to overcome the analytical challen...

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Literature Corpus work: bfb0a35a-e292-543b-86bf-6902a9f9c015
DOI: 10.1101/2023.09.14.557399

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