Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pseudotyped virus infection of multiplexed ACE2 libraries reveals SARS-CoV-2 variant shifts in receptor usage.

PLoS pathogens - 1 May 2024

Shukla Nidhi, Roelle Sarah M, Snell John C, DelSignore Olivia, Bruchez Anna M, Matreyek Kenneth A

Abstract excerpt

Pairwise compatibility between virus and host proteins can dictate the outcome of infection. During transmission, both inter- and intraspecies variabilities in receptor protein sequences can impact cell susceptibility. Many viruses possess mutable viral entry proteins and the patterns of host compatibility can shift as the viral protein sequence changes. This combinatorial sequence space between virus and host is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin-Converting Enzyme 2
Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Mutation

Share to Receptors, Virus

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 38768238
DOI: 10.1371/journal.ppat.1012044
PMCID: PMC11142672

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pseudotyped virus infection of multiplexed ACE2 libraries reveals SARS-CoV-2 variant shifts in receptor usage.PMID 38768238Read ↗

Pseudotyped virus infection of multiplexed ACE2 libraries reveals SARS-CoV-2 variant shifts in receptor usageSemantic proximity Read ↗

Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike proteinSemantic proximity Read ↗

Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infectionSemantic proximity Read ↗

Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein.Semantic proximity Read ↗

Cell type-specific adaptation of the SARS-CoV-2 spikeSemantic proximity Read ↗

Neutralisation resistance of SARS-CoV-2 spike-variants is primarily mediated by synergistic receptor binding domain substitutions.Semantic proximity Read ↗

Yeast surface display-based identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian speciesSemantic proximity Read ↗

Epistasis and background dependence in the evolution of Omicron variants of the SARS-CoV-2 Spike proteinSemantic proximity Read ↗

Variations in cell-surface ACE2 levels alter direct binding of SARS-CoV-2 Spike protein and viral infectivity: Implications for measuring Spike protein interactions with animal ACE2 orthologsSemantic proximity Read ↗

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and NeutralizationSemantic proximity Read ↗

Yeast surface display-based identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian species.Semantic proximity Read ↗

In silico comparison of spike protein-ACE2 binding affinities across species; significance for the possible origin of the SARS-CoV-2 virusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.