Article

Small-Molecule <i>In Vitro</i> Inhibitors of the Coronavirus Spike – ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2

2020-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Inhibitors of the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2, which acts as a ligand-receptor pair that initiates the viral attachment and cellular entry of this coronavirus causing the ongoing COVID-19 pandemic, are of considerable interest as potential antiviral agents. While blockade of such PPIs with small molecules is more challenging than with antibodie...

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Literature Corpus work: 30610c24-b06f-5d0e-928a-6e6bb91175dd
DOI: 10.1101/2020.10.22.351056

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