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Article

Mass Photometry Reveals Distinct ACE2 Binding Stoichiometries across SARS-CoV-2 Omicron Subvariants.

The journal of physical chemistry. B - 14 May 2026

Hsiao Wei-Cheng, Chiang Tsung-Sheng, Tsai Yu-Xi, Hsu Min-Feng, Hsu Shang-Te Danny

Abstract excerpt

Since late 2021, the SARS-CoV-2 Omicron variant has rapidly accumulated mutations in its spike (S) protein, leading to increased transmissibility and immune evasion. The COVID-19 pandemic caused by SARS-CoV-2 infections poses a significant global health challenge. While the binding affinity of Omicron S proteins to host receptor ACE2 has been extensively characterized, the binding stoichiometry across subvariants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42060859
DOI: 10.1021/acs.jpcb.6c00027
PMCID: PMC13181760

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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