Article

Narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neurons

2021-09-24

Abstract excerpt

Narcolepsy with cataplexy is a chronic sleep disorder characterized by hypocretin deficiency. The condition is believed to result from autoimmune destruction of hypocretin (HCRT) neurons, although direct evidence is lacking and mere Hcrt gene inactivation causes full-blown narcolepsy in mice. Here we show that the expression of another hypothalamic neuropeptide, QRFP, is lost in mouse models with HCRT cell-ablati...

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Literature Corpus work: 6910517e-5dba-52a4-906c-0e78f74fc21a
DOI: 10.1101/2021.09.21.461046

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