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Article

Sex-specific gene expression signatures of calcific aortic valve stenosis in a large collection of human tissues.

Atherosclerosis - 1 Jul 2026

Houessou Ursula, Zamani Pardis, Manikpurage Hasanga D, Li Zhonglin, Gaudreault Nathalie, Dahmene Manel, Dagenais François, Couture Christian, Clavel Marie-Annick, Pibarot Philippe, Mathieu Patrick, Bossé Yohan, Thériault Sébastien

Abstract excerpt

BACKGROUND AND AIMS: The mechanisms underlying sex differences in calcific aortic valve stenosis (CAVS) are poorly understood. We aimed to uncover sex-specific gene expression signatures of CAVS, including genes located on sexual chromosomes. METHODS: We performed mRNA sequencing from the explanted aortic valves of 500 individuals from our institute who underwent aortic valve replacement (n = 440) or a heart...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42214298
DOI: 10.1016/j.atherosclerosis.2026.120791

Genes

DMP1
MEPE
GYG2
MMP12
PRKX
PRSS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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