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Article

Neuropilin-1 sex-dependently modulates inflammatory, angiogenic and osteogenic phenotypes in the calcifying valve interstitial cell.

Biochemical pharmacology - 1 Aug 2024

Matilla Lara, Martín-Núñez Ernesto, Navarro Adela, Garaikoetxea Mattie, Fernández-Celis Amaya, Goñi-Olóriz Miriam, Gainza Alicia, Fernández-Irigoyen Joaquín, Santamaría Enrique, Tamayo Ibai, Álvarez Virginia, Sádaba Rafael, Jover Eva, López-Andrés Natalia

Abstract excerpt

The pathological mechanisms underlying the sex-dependent presentation of calcific aortic stenosis (AS) remain poorly understood. We aim to analyse sex-specific responses of valve interstitial cells (VICs) to calcific environments and to identify new pathological and potentially druggable targets. First, VICs from stenotic patients were modelled using pro-calcifying media (HP). Both male and female VICs were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38844264
DOI: 10.1016/j.bcp.2024.116336

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