Article
Sex-related differences in gene expression by porcine aortic valvular interstitial cells.
PloS one - 1 Jan 2012
McCoy Chloe M, Nicholas Dylan Q, Masters Kristyn S
Abstract excerpt
While many large-scale risk factors for calcific aortic valve disease (CAVD) have been identified, the molecular etiology and subsequent pathogenesis of CAVD have yet to be fully understood. Specifically, it is unclear what biological phenomena underlie the significantly higher occurrence of CAVD in the male population. We hypothesized the existence of intrinsic, cellular-scale differences between male and female...
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