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Article

Nuclear receptor LXR as a novel therapeutic antitumoral target in glioblastoma.

Cancer discovery - 1 Oct 2011

Moschetta Antonio

Abstract excerpt

Both primary and transformed cells need cholesterol for their growth. Guo and colleagues unraveled the connection between epidermal growth factor receptor mutations in glioblastoma and increased cholesterol influx via sterol regulatory element-binding protein 1 and low-density lipoprotein receptor (LDLR) increase. They propose the activation of the liver X receptor-inducible degrader of LDLR-LDLR axis as a...

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Share to Cell Death
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver X Receptors

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Share to Receptors, LDL

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Source

Identifiers

PMID: 22586629
DOI: 10.1158/2159-8290.CD-11-0228

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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