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Article

Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

13 Jul 2023

Abstract excerpt

Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM), but inevitably induces poorly understood global changes in GBM and its microenvironment (TME) that promote radio-resistance and recurrence. Through a cell surface marker screen, we identified that CD142 (tissue factor or F3) is robustly induced in the senescence-associated β-galactosidase (SA-βGal)-positive GBM cells after...

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PMID: 37451272
DOI: 10.1016/j.ccell.2023.06.007

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