Article

Trophoblast survival signaling during human placentation requires HIF-induced transcription of HSP70

2016-03-15

Abstract excerpt

Survival of trophoblast cells in the low oxygen environment of human placentation requires metalloproteinase-mediated shedding of HBEGF and downstream signaling. A matrix metalloproteinase (MMP) antibody array and quantitative RT-PCR revealed upregulation of MMP2 post-transcriptionally in human first trimester HTR-8/SVneo trophoblast cells and placental explants exposed to 2% O 2 . Specific MMP inhibitors establi...

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Literature Corpus work: bf185d09-3213-5c1a-822c-2d96d5457cdc
DOI: 10.1101/043851

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