Back to search

Article

Oxygen availability and hypoxia-independent action of HIF1α controls human trophoblast maturation and function

2025-12-15

Abstract excerpt

<h4>SUMMARY</h4> Placenta progenitor cells, also known as trophoblasts, initially specify at very low oxygen (O 2 ) concentrations. Across their differentiation path in the uterine microenvironment, they encounter a wide range of O 2 levels. Despite previous efforts, dissecting how these rapid and dynamic O 2 levels are sensed by trophoblast stem cells and transduced via hypoxia inducible factors (HIFs) has be...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f70b91d9-99be-5b9c-953b-1610b9874488
DOI
10.64898/2025.12.12.693923
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Oxygen availability and hypoxia-independent action of HIF1α controls human trophoblast maturation and functionDOI 10.64898/2025.12.12.693923
Low oxygen promotes extravillous trophoblast progenitor expansion but restrains maturationSemantic proximity
Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.Semantic proximity
Trophoblast lineage specification, differentiation and their regulation by oxygen tensionSemantic proximity
Low oxygen enhances trophoblast column growth by potentiating the extravillous lineage and promoting LOX activitySemantic proximity
Hypoxia Directs Human Extravillous Trophoblast Differentiation in a Hypoxia-Inducible Factor–Dependent MannerSemantic proximity
Hypoxia and Placental DevelopmentSemantic proximity
Low oxygen enhances trophoblast column growth by potentiating differentiation of the extravillous lineage and promoting LOX activitySemantic proximity
Trophoblast biology, responses to hypoxia and placental dysfunction in preeclampsiaSemantic proximity
Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restrictionSemantic proximity
Regulation of Human Placental Development by Oxygen TensionSemantic proximity
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interfaceSemantic proximity
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interfaceSemantic proximity
Select a neighboring publication to make it the new centre.