Article
Establishment and characterization of a human first-trimester extravillous trophoblast cell line (TEV-1).
Journal of the Society for Gynecologic Investigation - 1 May 2005
Feng Hui Chen, Choy Mei Yee, Deng Wen, Wong Hing Lok, Lau Wui Man, Cheung Annie N Y, Ngan Hextan Y S, Tsao Sai Wah
Abstract excerpt
OBJECTIVE: Research into the biology of human trophoblast invasion has been hampered by a lack of in vitro models. The aim of this study was to establish and characterize a human extravillous trophoblast cell line from the first-trimester placenta. METHODS: Human papillomavirus type 16 (HPV16) E6/E7 genes were stably expressed in primary cultures of first-trimester placenta via a retroviral vector (pLXSN-E6/E7)....
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