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Expression, Ontogeny, and Regulation of Hypoxia-Inducible Transcription Factors in the Human Placenta1

1 Aug 2000

Abstract excerpt

Placental hypoxia likely plays an important role in both normal placental development and pathology. Yet, the molecular mechanisms of hypoxia signaling in this organ are virtually unexplored. Therefore, we investigated the expression of the hypoxia inducible transcription factors (HIF) in normal human placentas spanning the first trimester to term. Several key observations emerged: 1) HIF-1 alpha and -2 alpha...

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PMID: 10906065
DOI: 10.1095/biolreprod63.2.559

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