Article

Low oxygen promotes extravillous trophoblast progenitor expansion but restrains maturation

2025-10-30

Abstract excerpt

<h4>SUMMARY</h4> Placental development occurs in a low oxygen environment, yet how oxygen tension instructs differentiation of progenitor cytotrophoblasts (CTB) along the extravillous versus villous pathways remains incompletely understood. In particular, the role of low oxygen in early extravillous trophoblast (EVT) progenitor expansion and subsequent maturation has been difficult to assess due to the lack of mo...

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Literature Corpus work: d9751ec5-4ff3-5243-94c1-3cce5653c721
DOI: 10.1101/2025.10.29.685387

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