Article

Assessing the risk stratification of breast cancer polygenic risk scores in two Brazilian samples

2022-09-10

Abstract excerpt

<h4>ABSTRACT</h4> Polygenic risk scores (PRS) for breast cancer (BC) have a clear clinical utility in risk prediction. PRS transferability across populations and ancestry groups is hampered by population-specific factors, ultimately leading to differences in variant effects, such as linkage disequilibrium (LD) and differences in variant frequency (AF-diff). Thus, locally-sourced population-based phenotypic and gen...

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Literature Corpus work: bf0809a1-5f3a-5d43-8873-cbab2dab53ba
DOI: 10.1101/2022.09.09.22279721

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