Article

Limitations in next-generation sequencing-based genotyping of breast cancer polygenic risk score loci

2023-12-17

Abstract excerpt

Considering polygenic risk scores (PRSs) in individual risk prediction is increasingly becoming the standard in genetic testing for hereditary breast cancer (BC). To calculate individual BC risks, the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) with inclusion of the BCAC 313 or the BRIDGES 306 BC PRS is commonly used. Meaningful incorporation of PRSs relies on repro...

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Literature Corpus work: 431f5240-aa9a-5d97-bcae-480228ff221a
DOI: 10.1101/2023.12.15.23298835

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