Article

Polygenic risk of type 2 diabetes is associated with Vascular Dementia but not with Alzheimer's Disease: a Prospective Cohort Study

2022-08-29

Abstract excerpt

<h4>Background: </h4> and Objectives Type 2 diabetes and dementia are associated, but their causal relationship is unclear. Genetic studies, i.e. using polygenic risk scores (PRS) or Mendelian Randomization (MR), and validated dementia endpoints with high diagnostic precision (instead of register-based diagnoses) may clarify causal links between these two entities. Methods We tested associations between PRS for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bf06a0d7-7bc0-5cd6-91a3-642792da677c
DOI: 10.21203/rs.3.rs-1996829/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic risk of type 2 diabetes is associated with Vascular Dementia but not with Alzheimer's Disease: a Prospective Cohort StudyDOI 10.21203/rs.3.rs-1996829/v1Read

Polygenic risk of type 2 diabetes is associated with incident vascular dementia: a prospective cohort studySemantic proximity Read

Type 2 diabetes and late-onset Alzheimer's disease and related dementia: A longitudinal cohort study integrating polygenic risk score.Semantic proximity Read

Type-2 diabetes and risk of dementia: observational and Mendelian randomisation studies in 1 million individuals.Semantic proximity Read

Causal Effects of Type 2 Diabetes and Glycemic Traits on Dementia and Stroke: A Mendelian Randomization Study including Imaging EndpointsSemantic proximity Read

Diabetic Phenotypes and Late-Life Dementia Risk: A Mechanism-specific Mendelian Randomization Study.Semantic proximity Read

Life's Essential 8, Polygenic Risk for Type 2 Diabetes, and Dementia: Evidence from the UK Biobank.Semantic proximity Read

Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years.Semantic proximity Read

Evaluating the causal association between type 2 diabetes and Alzheimer's disease: a Two-Sample Mendelian Randomisation StudySemantic proximity Read

Evaluating the Causal Effect of Type 2 Diabetes on Alzheimer's Disease Using Large-Scale Genetic Data.Semantic proximity Read

Age at type 2 diabetes onset and risk of dementia: The modifying role of genetic susceptibility and mitochondrial function.Semantic proximity Read

Evaluating the Causal Association Between Type 2 Diabetes and Alzheimer’s Disease: A Two-Sample Mendelian Randomization StudySemantic proximity Read

Mendelian randomization study of diabetes and dementia in the Million Veteran ProgramSemantic proximity Read