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Age at type 2 diabetes onset and risk of dementia: The modifying role of genetic susceptibility and mitochondrial function.

The journal of nutrition, health & aging - 1 Mar 2026

Dong Wanqing, Yuan Qibin, Wu Benrui, Gao Shiteng, Zhang Yingyu, Pan Ying, Zhou Kaixin, Jiang Hongwei

Abstract excerpt

OBJECTIVES: To assess dementia risk after incident type 2 diabetes (T2D) by age at diagnosis and evaluate modification by treatment, genetic susceptibility, and mitochondrial function. DESIGN: Prospective 1:1 age- and sex-matched cohort study using inverse-probability-weighted Cox models. SETTING: Kunshan Aging Research with E-health (KARE) cohort in China (2018-2024). PARTICIPANTS: 42,514 adults without diabetes...

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Identifiers

PMID: 41548335
DOI: 10.1016/j.jnha.2026.100780
PMCID: PMC12854030

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