Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Type 2 diabetes and late-onset Alzheimer's disease and related dementia: A longitudinal cohort study integrating polygenic risk score.

Journal of Alzheimer's disease : JAD - 1 May 2025

Jeong Sohyun, Lin Lisha, Leone Alvaro-Pascual, Hsu Yi-Hsiang

Abstract excerpt

BackgroundThe inherent genetic effects were not established between type 2 diabetes (T2DM) and Alzheimer's disease and related dementia (ADRD).ObjectiveWe aimed to investigate the association between T2DM and ADRD by integrating T2DM polygenic risk score (PRS) and applying matching in every subgroup.MethodsWe utilized UK Biobank First-occurrences datasets. T2DM were 1:1 matched to non-T2DM using propensity scores...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Dementia

Share to Diabetes Mellitus, Type 2

Share to Genetic Risk Score

Share to Longitudinal Studies

Share to Multifactorial Inheritance

Source

Identifiers

PMID: 40129417
DOI: 10.1177/13872877251326107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Type 2 diabetes and late-onset Alzheimer's disease and related dementia: A longitudinal cohort study integrating polygenic risk score.PMID 40129417Read ↗

Polygenic risk of type 2 diabetes is associated with incident vascular dementia: a prospective cohort studySemantic proximity Read ↗

Polygenic risk of type 2 diabetes is associated with Vascular Dementia but not with Alzheimer's Disease: a Prospective Cohort StudySemantic proximity Read ↗

Type-2 diabetes and risk of dementia: observational and Mendelian randomisation studies in 1 million individuals.Semantic proximity Read ↗

Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan.Semantic proximity Read ↗

Life's Essential 8, Polygenic Risk for Type 2 Diabetes, and Dementia: Evidence from the UK Biobank.Semantic proximity Read ↗

Polygenic risk score refines cardiovascular disease risk in individuals with type 2 diabetes at borderline or intermediate risk.Semantic proximity Read ↗

Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk scoreSemantic proximity Read ↗

Polygenic score analysis identifies distinct genetic risk profiles in Alzheimer’s disease comorbiditiesSemantic proximity Read ↗

Age at type 2 diabetes onset and risk of dementia: The modifying role of genetic susceptibility and mitochondrial function.Semantic proximity Read ↗

Polygenic risk score analysis suggests hypothyroidism as a risk factor for Alzheimer’s diseaseSemantic proximity Read ↗

Could personalised risk prediction for type 2 diabetes using polygenic risk scores direct prevention, enhance diagnostics, or improve treatment?Semantic proximity Read ↗

A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular-kidney complications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.