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Life's Essential 8, Polygenic Risk for Type 2 Diabetes, and Dementia: Evidence from the UK Biobank.

Nutrients - 25 Jun 2026

Li Yuanjing, Ekblom Örjan, Bucha Bikram, Cojocari Ariana, Wang Hui-Xin, Wang Rui

Abstract excerpt

BACKGROUND/OBJECTIVES: It is unclear if adherence to healthy guidelines can modify the association between polygenic risk score (PRS) for type 2 diabetes and dementia. This study aimed to investigate interrelationships between PRS for type 2 diabetes, Life's Essential 8 (LE8) metrics, and dementia. METHODS: We included 437,732 UK Biobank participants aged ≥40 years between 2006 and 2010. PRS for type 2 diabetes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42451084
DOI: 10.3390/nu18132080
PMCID: PMC13363298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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