Article

Structural basis of SARS-Cov-2 spike recognition by engineered synthetic multivalent VHH antibodies

2024-10-02

Abstract excerpt

High-throughput technologies such as next-generation sequencing (NGS), microarray-based gene synthesis, and phage display have empowered the discovery and engineering of precisely defined, synthetic antibodies with high avidity and drug-like features. Here, we describe a scalable process for engineering homo- and hetero-hexavalent variable domains of camelid heavy-chain (VHH)-Fc antibodies against the severe acute...

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Literature Corpus work: bf0159de-6029-50cb-96c4-1dad9afadeb1
DOI: 10.1101/2024.10.02.616254

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