Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2.

Viruses - 3 Nov 2021

Tang Qilong, Owens Raymond J, Naismith James H

Abstract excerpt

Nanobodies are 130 amino acid single-domain antibodies (VHH) derived from the unique heavy-chain-only subclass of Camelid immunogloblins. Their small molecular size, facile expression, high affinity and stability have combined to make them unique targeting reagents with numerous applications in the biomedical sciences. The first nanobody agent has now entered the clinic as a treatment against a blood disorder....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Antibodies, Viral
Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes

Share to Protein Interaction Domains and Motifs

Share to SARS-CoV-2

Share to Single-Domain Antibodies

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 34835020
DOI: 10.3390/v13112214
PMCID: PMC8625641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2.PMID 34835020Read ↗

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.Semantic proximity Read ↗

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2Semantic proximity Read ↗

A bivalent spike-targeting nanobody with anti-sarbecovirus activitySemantic proximity Read ↗

Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escapeSemantic proximity Read ↗

Versatile, Multivalent Nanobody Cocktails Efficiently Neutralize SARS-CoV-2Semantic proximity Read ↗

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2Semantic proximity Read ↗

Nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variantsSemantic proximity Read ↗

Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virusSemantic proximity Read ↗

A Spike Trimer Dimer-Inducing Nanobody with Anti-Sarbecovirus ActivitySemantic proximity Read ↗

Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies.Semantic proximity Read ↗

A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variantsSemantic proximity Read ↗

Structural basis of SARS-Cov-2 spike recognition by engineered synthetic multivalent VHH antibodiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.