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Article

Impact of dapagliflozin on metabolic phenotype, hormone levels, and fertility in female mice after prolonged high-fat diet.

Frontiers in endocrinology - 1 Jan 2024

Chen Xiaolin, Xiao Zhuoni, Dai Na, Fan Mingxia

Abstract excerpt

Introduction: A long-term high-fat diet (HFD) cause obesity and infertility through hypothalamic inflammation and insulin resistance, leading to metabolic abnormalities and ovulation dysfunction. The sodium-glucose cotransporter 2 inhibitors (SGLT2i) have emerged as a treatment for type 2 diabetic patients, regulating adipose tissue metabolism, hypothalamic inflammation, and ovulation in women with polycystic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39906039
DOI: 10.3389/fendo.2024.1457268
PMCID: PMC11791800

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