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Article

A Novel Self-Amplifying mRNA with Decreased Cytotoxicity and Enhanced Protein Expression by Macrodomain Mutations.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Nov 2024

Gong Yue, Yong Danni, Liu Gensheng, Xu Jiang, Ding Jun, Jia William

Abstract excerpt

The efficacy and safety of self-amplifying mRNA (saRNA) have been demonstrated in COVID-19 vaccine applications. Unlike conventional non-replicating mRNA (nrmRNA), saRNA offers a key advantage: its self-replication mechanism fosters efficient expression of the encoded protein, leading to substantial dose savings during administration. Consequently, there is a growing interest in further optimizing the expression...

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Identifiers

PMID: 39313862
DOI: 10.1002/advs.202402936
PMCID: PMC11578319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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