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mRNA vaccine sequence and structure design and optimization: Advances and challenges

26 Nov 2024

Abstract excerpt

Messenger RNA (mRNA) vaccines have emerged as a powerful tool against communicable diseases and cancers, as demonstrated by their huge success during the coronavirus disease 2019 (COVID-19) pandemic. Despite the outstanding achievements, mRNA vaccines still face challenges such as stringent storage requirements, insufficient antigen expression, and unexpected immune responses. Since the intrinsic properties of...

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PMID: 39608721
DOI: 10.1016/j.jbc.2024.108015

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